Fenofibrate API
IOL Chemicals and Pharmaceuticals Limited Expertise in Fenofibrate:
IOLCP’s manufacturing process involves using basic raw materials such as Anisole and 4-chlorobenzoyl chloride.
It’s a fully backward integrated process with dedicated facilities.
Several PSD grades are available.
Highest quality standards that meet all Pharmacopeial and ICH requirements.
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Mechanism of Action
Fenofibrate lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein CIII, which increases lipolysis and elimination of triglyceride-rich particles from plasma.
Fenofibrate enhance fatty acid oxidation via acyl CoA synthetase and other enzymes, further reducing triglycerides synthesis, overall reduction of plasma triglyceride and very-low-density lipoprotein (VLDL).
Indication
The main therapeutic indications are:
Fenofibrate is used to treat hypertriglyceridemia & primary hypercholesterolemia, It reduces low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, and apolipoprotein B and increases high-density lipoprotein cholesterol (HDL-C) in adults.
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