Fenofibrate API
IOL Chemicals and Pharmaceuticals Limited Expertise in Fenofibrate:
IOLCP’s manufacturing process involves using basic raw materials such as Anisole and 4-chlorobenzoyl chloride.
It’s a fully backward integrated process with dedicated facilities.
Several PSD grades are available.
Highest quality standards that meet all Pharmacopeial and ICH requirements.
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IOL Chemicals and Pharmaceuticals Limited Expertise in Fenofibrate:
IOLCP’s manufacturing process involves using basic raw materials such as Anisole and 4-chlorobenzoyl chloride.
It’s a fully backward integrated process with dedicated facilities.
Several PSD grades are available.
Highest quality standards that meet all Pharmacopeial and ICH requirements.
Mechanism of Action
Fenofibrate lowers lipid levels by activating peroxisome proliferator-activated receptor alpha (PPARα). PPARα activates lipoprotein lipase and reduces apoprotein CIII, which increases lipolysis and elimination of triglyceride-rich particles from plasma.
Fenofibrate enhance fatty acid oxidation via acyl CoA synthetase and other enzymes, further reducing triglycerides synthesis, overall reduction of plasma triglyceride and very-low-density lipoprotein (VLDL).
Indication
The main therapeutic indications are:
Fenofibrate is used to treat hypertriglyceridemia & primary hypercholesterolemia, It reduces low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, and apolipoprotein B and increases high-density lipoprotein cholesterol (HDL-C) in adults.
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