Pantoprazole Sodium API
Expertise in
Pantoprazole Sodium
Capability to produce both monohydrate and sesquihydrate forms of Pantoprazole.
Highest quality standards that meet all Pharmacopeial and ICH requirements in
manufacturing.
In situ process that ensures the shortening of the process time cycles
substantially.
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Mechanism of Action
Pantoprazole Sodium exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme at the secretory surface of gastric parietal cell.
The effect of this API leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus.
As the binding of pantoprazole to the (H+, K+)-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, the API’s duration of antisecretory effect persists longer than 24 hours.
Indication
The main therapeutic indications of API are:
It is used to treat patients having gastroesophageal reflux disease (GERD), erosive esophagitis, gastric acid hypersecretion,
and to promote healing of tissue damage caused by gastric acid.
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