Gabapentin API
IOL Chemicals and Pharmaceuticals Limited Expertise in Gabapentin:
IOLCP’s manufacturing
process involves using basic raw materials such as
Methyl
cyanoacetate and cyclohexanone.
Synthetic route doesn’t need to use CDA, eliminating the dependency
on other
countries.
It’s a fully backward integrated process with dedicated facilities.
Several PSD grades are available.
Highest quality standards that meet all Pharmacopeial and ICH requirements.
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IOL Chemicals and Pharmaceuticals Limited Expertise in Gabapentin:
IOLCP’s manufacturing
process involves using basic raw materials such as
Methyl
cyanoacetate and cyclohexanone.
Synthetic route doesn’t need to use CDA, eliminating the dependency
on other
countries.
It’s a fully backward integrated process with dedicated facilities.
Several PSD grades are available.
Highest quality standards that meet all Pharmacopeial and ICH requirements.
Mechanism of Action
Gabapentin modulates the action of the GABA synthetic enzyme, glutamic acid decarboxylase (GAD) and the glutamate synthesizing enzyme, branched-chain amino acid transaminase.
The primary mode of action of Gabapentin appears to be at the auxiliary α2δ-1 subunit of voltage-gated calcium channels (though a low affinity for the α2δ-2 subunit has also been reported). The primary function of these subunits is to facilitate the movement of pore-forming α1 subunits of calcium channels from the endoplasmic reticulum to the cell membrane of pre-synaptic neurons.
Gabapentin appears to inhibit the action of α2δ-1 subunits, thus decreasing the density of pre-synaptic voltage-gated calcium channels and the subsequent release of excitatory neurotransmitters. Likely, this inhibition is also responsible for the anti-epileptic action of gabapentin.
Indication
The main therapeutic indications are:
Gabapentin is used to treat postherpetic neuralgia and for the adjunctive treatment of partial-onset seizures.
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