Chemically, Ibuprofen is an organic acid and can be converted to different organic and inorganic salts, which are termed as Ibuprofen salts or derivatives of Ibuprofen. Being a chiral compound, Ibuprofen can also exist in two stereoisomeric forms - namely Levo and Dextro. Majority of the formulations that are available commercially use Ibuprofen in racemic form, or in a 50:50 mixture of Levo and Dextro stereoisomeric form. However, there are different types of derivatives of Ibuprofen that are sold globally.
1. Ibuprofen IP/EP/BP/USP/JP
2. Ibuprofen Sodium
3. Ibuprofen Lysinate
Ibuprofen Sodium is a newer and more soluble form that is absorbed faster than standard IBU, leading to a more rapid analgesia and patient compliance. Due to its higher solubility, compared to Ibuprofen (IBU), it is noted that Ibuprofen Sodium, or IBU(Na), has enhanced effectiveness and provides quick pain relief.
Similar to inorganic salt of Ibuprofen, IBU-Sodium, organic salt of Ibuprofen, that is, Ibu-Lysinate is also found to be absorbed faster than the Ibuprofen. ‘Tlag’ (Time between dosing and start of action) and ‘TCmaxRef’ (observed maximum plasma concentration) demonstrate early start and increased speed of absorption of salts compared with the reference, and may predict the more rapid onset of analgesia.
Racemic Ibuprofen and Dexibuprofen differ in their physicochemical properties, Levo form (50% in Ibuprofen) can exhibit pharmacological action only after conversion into Dexibuprofen. Based on these results, it can be assumed that an identical pharmacological efficacy could be exerted by smaller doses of Dex- Ibuprofen instead of racemic Ibuprofen, and this may be a potential method to decrease side-effects. The administration of Dex-Ibuprofen may offer the advantage of delivering Ibuprofen more efficiently, with a better safety profile than the Racemic Ibuprofen formulations.View our API Portfolio