Ibuprofen API is a non-steroidal anti- inflammatory drug (NSAID) and a non-selective COX 1 & 2 inhibitor.
Drug Class
Manufactured through a fully backward integrated process, ensuring complete control and efficiency.
Expertise
US/EU/ANVISA/NMPA
Regulatory Filings
IOLCP holds the mantle as the largest manufacturer of Ibuprofen API. Its fully integrated facilities allow seamless production and supply.
Manufacturing Leadership
Compliant with ICH and Pharmacopeial regulations, IOLCP maintains the highest quality standards for every batch and ensures comprehensive management of all non- genotoxic and mutagenic contaminants.
Quality Standards
IOLCP currently commands a substantial Ibuprofen API production capacity exceeding 12,000 MT annually, with a strategic plan to increase its derivatives capacity by an additional 500 MT in the upcoming quarter.
Extensive Production Capacity
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IOLCP Global leader in Ibuprofen API
IOL Chemicals and Pharmaceuticals Limited is the world’s largest and only manufacturer of Ibuprofen, with two fully backward-integrated facilities in Barnala, India and global regulatory approvals including USFDA, EUGMP, ANVISA, KFDA and NMPA. Our backward integration provides unique control over the entire Ibuprofen manufacturing process, setting us distinctly apart in the Ibuprofen API market through superior quality, consistency, and supply reliability. This integrated model also helps customers navigate fluctuations in Ibuprofen API price with greater confidence and long-term supply assurance.
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- Multiple PSD Grades: IOLCP offers several PSD (Particle Size Distribution) grades for Ibuprofen, catering to diverse pharmaceutical needs.
- Pharmaceutical Salt Formulations: IOLCP provides a wide range of pharmaceutically acceptable salt formulations of Ibuprofen, including Ibuprofen Sodium dihydrate and Ibuprofen Lysinate, customized according to client requirements.
- Ibuprofen Derivatives: Ibuprofen can be transformed into various organic and inorganic salts, such as Ibuprofen Sodium dihydrate and Lysinate. These derivatives enhance solubility and absorption, providing faster onset of action compared to standard Ibuprofen.
- Chiral Nature of Ibuprofen: As a chiral compound, Ibuprofen exists in two stereoisomeric forms—Levo and Dextro. While most formulations use the racemic form (a 50:50 mixture), Dex-Ibuprofen offers a more efficient pharmacological effect with a potentially better safety profile.
Indication
The main therapeutic indications of API are:
It is used to reduce fever and treat pain or inflammation caused by many conditions
such
as
headache,
toothache, back pain, arthritis, menstrual cramps, or minor
injury.
Product Portfolio
Frequently Asked Questions
Ibuprofen API forms the active pharmaceutical ingredient in ibuprofen-based medication. This API provides therapeutic effects such as pain relief, reduced inflammation, and fever reduction, making it a widely used medication for various conditions.
The Ibuprofen API works by inhibiting the COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins. These lipid molecules play a crucial role in triggering inflammation, pain, & fever. By reducing their synthesis, ibuprofen provides effective relief from these symptoms.
The most common Ibuprofen API uses include mild to moderate pain like headaches, menstrual cramps, and dental discomfort. It is effective in reducing inflammation in conditions such as arthritis and helps in lowering fever, providing a broad range of therapeutic benefits.
Ibuprofen API manufacturers need to follow strict environmental considerations. This includes reducing carbon emissions, managing waste byproducts, & adopting sustainable practices to comply with global regulations. Also, green chemistry & waste management help minimise the environmental footprint.
IOLCP offers a range of Ibuprofen API products that includes Ibuprofen Sodium dihydrate API, a fast-absorbing form, Ibuprofen Lysinate API, known for quicker action, & Dex Ibuprofen API for effective pain relief. Each of these complies with ICH and pharmacopeial regulations & maintains the highest standard.
With a massive production capability of 12,000 metric tonnes per annum (MTPA), IOLCP stands tall as one of the largest Ibuprofen API manufacturers globally. This substantial capacity ensures that IOLCP is able to meet the rising demands of pharmaceutical companies with ease.
IOLCP’s Ibuprofen API is manufactured in facilities certified by top global regulators like USFDA, EUGMP, ANVISA, and EDQM (Certificate of Suitability). All these certifications highlight IOLCP’s prowess in producing Ibuprofen active pharmaceutical ingredient of the highest international standards.
As one of the leading Ibuprofen API manufacturer companies in India, IOLCP offers extensive support to clients, covering regulatory assistance, technical support, timely delivery, & after-sales service. This customer-centric approach ensures the smooth integration of IOLCP’s Ibuprofen API into pharmaceutical products while maintaining competitive Ibuprofen API prices.