Paracetamol API
IOL Chemicals and Pharmaceuticals Limited Expertise in Paracetamol
IOLCP produces paracetamol in a dedicated manufacturing unit. Facility is further
expandable as per market demand.
Access to all pharmacopeial grades with customizable PSD ranges & CEP in place.
Superior quality with stringent controls on all process impurities (Results: < 0.02%;
Limit: 0.05%).
Superior quality with stringent controls on all process impurities (Results: < 0.02%;
Limit: 0.05%).
Azoxy contaminant-free material (BDL; < 0.03 ppm) and Absence of all potential
genotoxic “nitro and aniline” impurities (BDL; < 0.03 ppm).
Full controls on all carcinogenic Nitrosamines (Not detected when tested
at 0.03 ppm levels).
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Mechanism of Action
Paracetamol inhibits prostaglandin synthesis in intact cells in vitro when the levels of the substrate arachidonic acid are low, then prostaglandins are primarily synthesized by COX-2 in cells that contain both COX-1 and COX-2.
Analgesic effect of paracetamol is central due to the activation of descending serotonergic pathways, but its primary site of action is the inhibition of Prostaglandin synthesis.
Indication
The main therapeutic indications are:
Paracetamol is used as pain reliever and fever reducer.
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