Losartan Potassium API
IOL Chemicals and Pharmaceuticals Limited Expertise in Losartan potassium
IOLCP’s major strength lies in complete backward integration starting from very basic raw materials such as Ortho-chlorotoluene.
Losartan from IOLCP is completely free from all Nitrosamines for e.g. NDMA, NDEA, NDBA etc.
In addition to this,IOLCP has established a novel process to remove Azido impurity to less than 1 ppm.
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Mechanism of Action
Losartan is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers blood pressure in hypertensive individuals.
It blocks all overt actions of angiotensin-2 such as Vasoconstriction, Central & Peripheral sympathetic stimulus, Release of aldosterone and adrenaline, Salt and water reabsorption, Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.
Indication
The main therapeutic indications are:
Losartan is used to treat hypertension, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
Additionally, Losartan also used to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes.
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